Twitter  |    LinkedIn

Putting the Brakes on Autoimmunity: Checkpoint Agonists in Dermatology

AIDlogo_final_color

The Dermatology Innovation Webinar was held on Tuesday, November 1, 2023.  Webinar registration was complimentary because of the generosity of AID's sponsors.

Putting the Brakes on Autoimmunity: Checkpoint Agonists in Dermatology

Program

Welcome

Jamie Breslin, PhD, Executive Director, Advancing Innovation in Dermatology, Inc
11:00 AM
 
Overview
Adam Raff, MD, PhD, FAAD, Vice President, Clinical Development, EQRx
11:05 AM
(recording timestamp - 0:02:48)
 
Restoration of Immune Balance with a BTLA Agonist, ANB032: Exploring a Potential New Treatment Paradigm for AD
Paul F Lizzul, MD, PhD, Chief Medical Officer, AnaptysBio
11:15 AM
(recording timestamp - 0:10:28)
 
Clinical Development of PD-1 and CD200R Agonists 
    Paul Klekotka, MD, PhD, FAAD, Vice President, Immunology, Lilly Research Laboratories
11:35 AM
(recording timestamp - 0:33:21
 
TIGIT as a therapeutic target for autoimmunity
Nicole Joller, PhD, Professor for Immunology, Department of Quantitative Biomedicine, University of Zurich
12:05 PM
(recording timestamp - 0:54:42)
 
PD-1H (VISTA) as a potential target in inflammatory skin diseases
Matthew Vesely MD, PhD, Assistant Professor, Department of Dermatology, Yale School of Medicine
12:25 PM
(recording timestamp - 1:18:07)
 
Moderated Q&A with speakers
Adam Raff, MD, PhD, FAAD, Vice President, Clinical Development, EQRx
12:45 PM
(recording timestamp - 1:37:48)

Webinar Takeaways

  • Understand the evolution of immune checkpoints in cancer immunotherapy and their implications for autoimmune diseases
  • Learn how checkpoint agonist therapies are being studied in clinical trials
  • Discover novel checkpoint targets and their potential as targets in inflammatory skin diseases

Watch Now

Advancing Innovation in Dermatology, Inc. is a registered IRS 501(c)(3) organization designated as a public charity in the United States.  

Webinar registration is complimentary because of the generosity of AID's sponsors.

Webinar Speakers

AID_Nov1_Adam Raff

Adam Raff, MD, PhD, FAAD

Vice President, Clinical Development; EQRx

Dr. Raff is a physician-scientist, drug developer, and board-certified dermatologist. He is a Vice President in Clinical Development at EQRx working to develop innovative medicines within inflammation and immunology. Dr. Raff previously served as the Director of Translational Medicine at LEO Pharma. He is an Instructor at Harvard Medical School and maintains a clinical dermatology practice at Beth Israel Lahey Health. He previously worked at the Massachusetts General Hospital and the Wellman Center for Photomedicine. He received his MD/PhD at the University of Southern California, completed his dermatology residency at Harvard, and his post-doctoral fellowship as an NIH-funded T32 fellow under R. Rox Anderson MD at the Wellman Center for Photomedicine. Dr. Raff is a member of the AID Research Leadership Council, was a founding member of the AID Education Committee, and previously served as AID Education Committee Chair, Virtual Magic Wand Co-Chair, and Director of the Hacking Dermatology Initiative. 

AID_Nov1_Nicole Joller

Nicole Joller, PhD

Professor for Immunology; Department of Quantitative Biomedicine; University of Zurich

Dr. Joller is an Associate Professor for Immunology at the University of Zurich and studies how preceding immune challenges shape the immune system and thereby influence diseases susceptibility. Stemming from her desire to understand why the immune system induces beneficial or detrimental responses when faced with different challenges, Dr. Joller has a background in different aspects of immunology. She obtained her PhD at ETH Zurich studying the immune response to infections. She then changed perspectives with her post-doctoral fellowship with Dr. Vijay Kuchroo at Harvard Medical School in Boston to work on autoimmunity and co-inhibitory receptors, particularly TIGIT. In her research group in Zurich, Dr. Joller combines her two fields of expertise to study immune regulation in infectious settings. Particularly, she is interested in how co-inhibitory receptors contribute to regulatory T cell specialization and how they affect pathogen persistence and tissue homeostasis.

AID_Nov1_Paul Klekotka

Paul Klekotka, MD, PhD, FAAD

Vice President, Immunology; Lilly Research Laboratories

Dr. Klekotka is a board-certified dermatologist and physician-scientist with extensive early phase and late phase clinical development experience. He earned his MD and PhD degrees and completed his dermatology residency at Washington University in St Louis. Following residency, he was an Instructor of Medicine in the Dermatology Division and Post-doc in Immunology at Washington University School of Medicine. Next, he moved to Amgen where he worked in clinical development across multiple therapeutic areas.  Then he went to Eli Lilly and Company where he is currently Vice President of Immunology Clinical Research in San Diego where he leads the early phase immunology clinical group.  

AID_Nov1_Paul F Lizzul

Paul F Lizzul, MD, PhD

Chief Medical Officer; AnaptysBio

Dr. Paul F. Lizzul, a physician scientist and entrepreneur, is the Chief Medical Officer of AnaptysBio, focused on delivering innovative immunology therapeutics to patients.  Dr Lizzul leads the company’s comprehensive development organization, spanning clinical development, translational medicine, clinical operations, regulatory affairs, data sciences, medical affairs, clinical pharmacology and toxicology.  Prior to joining AnaptysBio, he held positions in diverse organizations including Global Development Lead for Inflammation at Amgen, Chief Medical Officer of Sienna Biopharmaceuticals and Senior Medical Director at Kythera Biopharmaceuticals.  Dr. Lizzul is also a volunteer faculty member in the division of dermatology at the David Geffen School of Medicine at UCLA.  Prior to transitioning into biotech leadership roles Dr. Lizzul was an Assistant Professor of Dermatology and Associate Director of Clinical Research at the Tufts Medical Center.  He is a board-certified dermatologist, a faculty member of the American Academy of Dermatology and has also served on the United States Food and Drug Administration (FDA) Dermatology and Ophthalmic Drugs Advisory Committee.  Dr. Lizzul received his M.D., Ph.D. in molecular genetics and M.P.H. in epidemiology from the Robert Wood Johnson Medical School at Rutgers. He has also earned an M.B.A. in entrepreneurship from the Rutgers Business School.

AID_Nov1_Matthew Vesely

Matthew Vesely MD, PhD

Assistant Professor; Department of Dermatology; Yale School of Medicine

Dr. Vesely is an Assistant Professor in Dermatology at Yale School of Medicine with research training in immunology and clinical expertise in chronic inflammatory skin diseases and cancer immunotherapy. He completed his MD and PhD degrees at Washington University in St. Louis before completing his dermatology residency at Yale School of Medicine. During his post-doctoral fellowship with Dr. Lieping Chen at Yale, Dr. Vesely investigated immune inhibitory receptor V-domain Ig suppressor of T cell activation (VISTA) as a potential therapeutic target for cutaneous lupus. His research program uses spatial proteomics and spatial transcriptomics to visualize the immunopathogenesis of autoimmune skin diseases with a particular emphasis on immune inhibitory receptors that may be stimulated for future autoimmune disease therapy. 

AID_Nov1_Matthew Vesely

Matthew Vesely MD, PhD

Assistant Professor; Department of Dermatology; Yale School of Medicine

Dr. Vesely is an Assistant Professor in Dermatology at Yale School of Medicine with research training in immunology and clinical expertise in chronic inflammatory skin diseases and cancer immunotherapy. He completed his MD and PhD degrees at Washington University in St. Louis before completing his dermatology residency at Yale School of Medicine. During his post-doctoral fellowship with Dr. Lieping Chen at Yale, Dr. Vesely investigated immune inhibitory receptor V-domain Ig suppressor of T cell activation (VISTA) as a potential therapeutic target for cutaneous lupus. His research program uses spatial proteomics and spatial transcriptomics to visualize the immunopathogenesis of autoimmune skin diseases with a particular emphasis on immune inhibitory receptors that may be stimulated for future autoimmune disease therapy.